Generation of human induced pluripotent stem cell lines from two patients affected by catecholamine-induced QT prolongation (CIQTP)

Bastien Cimarosti; Robin Canac; Aurore Girardeau; Marine Arnaud; Quentin Francheteau; Vincent Probst; Patricia Lemarchand; Richard Redon; Jean-Baptiste Gourraud; Nathalie Gaborit; Guillaume Lamirault

doi:10.1016/j.scr.2021.102649

Generation of human induced pluripotent stem cell lines from two patients affected by catecholamine-induced QT prolongation (CIQTP)

Stem Cell Res. 2022 Mar:59:102649. doi: 10.1016/j.scr.2021.102649. Epub 2021 Dec 30.

Affiliations

¹ Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
² Université de Nantes, CHU Nantes, INSERM, CNRS, SFR Santé, FED 4203, INSERM UMS 016, CNRS UMS 3556, F-44000 Nantes, France.
³ Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France. Electronic address: guillaume.lamirault@univ-nantes.fr.

PMID: 34995842
DOI: 10.1016/j.scr.2021.102649

Abstract

Catecholamine-induced QT prolongation (CIQTP) is an inherited cardiac disease characterized by a normal baseline ECG and a risk of sudden cardiac death by ventricular arrhythmia due to a QT prolongation that only appears during catecholergic stimulation, especially mental stress. Induced pluripotent stem cells (hiPSCs) were generated from peripheral blood mononuclear cells collected from two CIQTP-affected patients from two different families. These two hiPSC lines are a valuable model to study biological alterations due to CIQTP.