A CLUSTER OF SARS-COV-2 DELTA VARIANT OF CONCERN ADDITIONALLY HARBORING F490S, NORTHERN LOMBARDY, ITALY

Federica Novazzi; Andreina Baj; Renee Pasciuta; Angelo Genoni; Francesca Drago Ferrante; Rosalia Tripiciano; Giuseppe Catanoso; Daniele Focosi; Fabrizio Maggi

doi:10.1016/j.ijid.2021.12.362

A CLUSTER OF SARS-COV-2 DELTA VARIANT OF CONCERN ADDITIONALLY HARBORING F490S, NORTHERN LOMBARDY, ITALY

Int J Infect Dis. 2022 Mar:116:271-272. doi: 10.1016/j.ijid.2021.12.362. Epub 2022 Jan 4.

Authors

Federica Novazzi¹, Andreina Baj², Renee Pasciuta¹, Angelo Genoni³, Francesca Drago Ferrante¹, Rosalia Tripiciano⁴, Giuseppe Catanoso⁴, Daniele Focosi⁵, Fabrizio Maggi⁶

Affiliations

¹ Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy.
² Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: andreina.baj@uninsubria.it.
³ Department of Medicine and Surgery, University of Insubria, Varese, Italy.
⁴ ATS Insubria, Varese, Italy.
⁵ North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.
⁶ Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Abstract

The Delta variant of concern (VOC) of SARS-CoV-2 has become dominant worldwide. In this article, we report a cluster caused by B.1.617.2 harboring the additional mutation of concern (MOC) F490S. We observed that 5 fully vaccinated subjects aged between 47 and 84 years were infected with this variant. The immune escape mutation F490S, first identified in the Lambda VOI, appears to impair vaccine efficacy and is rapidly increasing in prevalence worldwide.

Keywords: B.1.617.2; COVID-19; Delta; F490S; SARS-CoV-2; variant of concern.

MeSH terms

Aged
Aged, 80 and over
COVID-19 Vaccines
COVID-19* / epidemiology
Humans
Middle Aged
Mutation
SARS-CoV-2* / genetics

Substances

COVID-19 Vaccines

Supplementary concepts

SARS-CoV-2 variants