Virus Infection of the Brain: Lessons from Drosophila for Illuminating Virus Disease and Nervous System Function

Ioannis Eleftherianos; Ghada Tafesh-Edwards

doi:10.1016/j.neuroscience.2021.12.036

Virus Infection of the Brain: Lessons from Drosophila for Illuminating Virus Disease and Nervous System Function

Neuroscience. 2022 Feb 21:484:80-82. doi: 10.1016/j.neuroscience.2021.12.036. Epub 2022 Jan 4.

Authors

Ioannis Eleftherianos¹, Ghada Tafesh-Edwards²

Affiliations

¹ Infection and Innate Immunity Lab, Department of Biological Sciences, Science and Engineering Hall, 800 22nd St NW, The George Washington University, Washington, DC 20052, USA. Electronic address: ioannise@gwu.edu.
² Infection and Innate Immunity Lab, Department of Biological Sciences, Science and Engineering Hall, 800 22nd St NW, The George Washington University, Washington, DC 20052, USA.

PMID: 34995715
DOI: 10.1016/j.neuroscience.2021.12.036

Abstract

Recent studies using genomic and functional approaches in the fruit fly Drosophila melanogaster have revealed the effects of viral infection on nervous system homeostasis. An established connection between viral infection and brain function is critical due to its significant contribution to several areas of biomedical research, particularly the molecular pathogenesis of neurotropic viruses, the neurobiology of viral disease, and understanding the genetic basis and pathophysiology of viral tropism.

Keywords: Drosophila; brain immune response; nervous system function; virus infection.

MeSH terms

Animals
Brain
Drosophila melanogaster / genetics
Drosophila*
Neurobiology
Virus Diseases* / genetics