Understanding the biological basis of psychiatric disease: What's next?

Cell. 2022 Jan 6;185(1):1-3. doi: 10.1016/j.cell.2021.12.010.

Abstract

Psychiatric disease is one of the greatest health challenges of our time. The pipeline for conceptually novel therapeutics remains low, in part because uncovering the biological mechanisms of psychiatric disease has been difficult. We asked experts researching different aspects of psychiatric disease: what do you see as the major urgent questions that need to be addressed? Where are the next frontiers, and what are the current hurdles to understanding the biological basis of psychiatric disease?

MeSH terms

  • Animals
  • Antidepressive Agents / therapeutic use*
  • Data Science / methods*
  • Depression / drug therapy*
  • Depression / genetics
  • Depression / metabolism*
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / genetics
  • Depressive Disorder / metabolism*
  • Genomics / methods*
  • Humans
  • Neurons / metabolism
  • Precision Medicine / methods*
  • Prefrontal Cortex / metabolism
  • Translational Research, Biomedical / methods*
  • Treatment Outcome

Substances

  • Antidepressive Agents