Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

Chen Cheng; Siavash K Kurdistani

doi:10.1016/j.molcel.2021.12.003

Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

Mol Cell. 2022 Jan 6;82(1):8-9. doi: 10.1016/j.molcel.2021.12.003.

Authors

Chen Cheng¹, Siavash K Kurdistani²

Affiliations

¹ Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
² Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: skurdistani@mednet.ucla.edu.

PMID: 34995510
DOI: 10.1016/j.molcel.2021.12.003

Abstract

Hsieh et al. (2022) reveal that carbon starvation elicits an unexpected compensatory reallocation of histone acetylation to establish an adaptive gene expression program, demonstrating how chromatin may integrate cellular carbon flow via histone acetylation with gene regulation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Acetylation
Carbon
Chromatin* / genetics
Gene Expression
Histones* / genetics
Histones* / metabolism
Organelles / metabolism

Substances

Chromatin
Histones
Carbon

Grants and funding

R01 GM140106/GM/NIGMS NIH HHS/United States