Forward steps in organoid-based forward screening

Melissa H Little; Sara E Howden

doi:10.1016/j.stem.2021.12.004

Forward steps in organoid-based forward screening

Cell Stem Cell. 2022 Jan 6;29(1):7-8. doi: 10.1016/j.stem.2021.12.004.

Authors

Melissa H Little¹, Sara E Howden²

Affiliations

¹ Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia; Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia. Electronic address: melissa.little@mcri.edu.au.
² Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia.

PMID: 34995496
DOI: 10.1016/j.stem.2021.12.004

Abstract

In this issue of Cell Stem Cell, Ungricht et al. (2022) perform a temporally controlled CRISPR/Cas9-based genome-wide screen in kidney organoids to uncover key gene networks important for the specification of kidney cell types from human pluripotent stem cells, thus furthering our understanding of human kidney development and disease.

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MeSH terms

Epithelial Cells
Humans
Kidney
Organogenesis
Organoids*
Pluripotent Stem Cells*