Enteric glia bring fresh WNT to the intestinal stem cell niche

Fränze Progatzky; Vassilis Pachnis

doi:10.1016/j.stem.2021.12.003

Enteric glia bring fresh WNT to the intestinal stem cell niche

Cell Stem Cell. 2022 Jan 6;29(1):3-4. doi: 10.1016/j.stem.2021.12.003.

Authors

Fränze Progatzky¹, Vassilis Pachnis²

Affiliations

¹ Development and Homeostasis of the Nervous System Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
² Development and Homeostasis of the Nervous System Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. Electronic address: vassilis.pachnis@crick.ac.uk.

PMID: 34995494
DOI: 10.1016/j.stem.2021.12.003

Abstract

Intestinal stem cells continuously self-renew and differentiate into a variety of specialized epithelial cells that maintain gut health. New research in this issue of Cell Stem Cell (Baghdadi et al., 2022) shows that enteric glial cells regulate the intestinal stem cell niche during regeneration and disease through the production of WNT ligands.

Enteric glia bring fresh WNT to the intestinal stem cell niche

Authors

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Abstract

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