Response of NOTCH1-Activated Tracheal Adenoid Cystic Carcinoma to the Gamma Secretase Inhibitor Nirogacestat

JCO Precis Oncol. 2021 Nov:5:1579-1583. doi: 10.1200/PO.21.00228.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Adenoid Cystic / drug therapy*
  • Carcinoma, Adenoid Cystic / genetics
  • Gamma Secretase Inhibitors and Modulators / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Receptor, Notch1 / genetics
  • Tetrahydronaphthalenes / therapeutic use*
  • Tracheal Neoplasms / drug therapy*
  • Tracheal Neoplasms / genetics
  • Treatment Outcome
  • Valine / analogs & derivatives*
  • Valine / therapeutic use

Substances

  • Gamma Secretase Inhibitors and Modulators
  • NOTCH1 protein, human
  • Receptor, Notch1
  • Tetrahydronaphthalenes
  • Valine
  • nirogacestat