Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy

Shivanand Pudakalakatti; Priyank Raj; Travis C Salzillo; José S Enriquez; Dontrey Bourgeois; Prasanta Dutta; Mark Titus; Shayan Shams; Priya Bhosale; Michael Kim; Florencia McAllister; Pratip K Bhattacharya

doi:10.1007/978-1-0716-2014-4_12

Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy

Methods Mol Biol. 2022:2435:169-180. doi: 10.1007/978-1-0716-2014-4_12.

Authors

Shivanand Pudakalakatti^#¹, Priyank Raj^#^{1

2}, Travis C Salzillo^{1

2}, José S Enriquez^{1

2}, Dontrey Bourgeois^{1

3}, Prasanta Dutta¹, Mark Titus⁴, Shayan Shams⁵, Priya Bhosale^{2

6}, Michael Kim^{2

7}, Florencia McAllister^{2

8}, Pratip K Bhattacharya^{9

10}

Affiliations

¹ Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
² MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA.
³ Department of Statistics, Rice University, Houston, TX, USA.
⁴ Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁵ Department of Biomedical Informatics, University of Texas Health Science Center, Houston, TX, USA.
⁶ Department of Abdominal Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁷ Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁸ Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁹ Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA. pkbhattacharya@mdanderson.org.
¹⁰ MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA. pkbhattacharya@mdanderson.org.

^# Contributed equally.

Abstract

There is an unmet need for noninvasive surrogate markers that can help identify premalignant lesions across different tumor types. Here we describe the methodology and technical details of protocols employed for in vivo ¹³C pyruvate metabolic imaging experiments. The goal of the method described is to identify and understand metabolic changes, to enable detection of pancreatic premalignant lesions, as a proof of concept of the high sensitivity of this imaging modality.

Keywords: 13C; Assessment of preventive responses; Early detection; HP-MR; Hyperpolarization; MRI; Metabolic imaging; Premalignancy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Carbon Isotopes / metabolism
Humans
Magnetic Resonance Imaging / methods
Precancerous Conditions*
Pyruvic Acid* / metabolism

Substances

Carbon Isotopes
Pyruvic Acid

Abstract

Publication types

MeSH terms

Substances

Grants and funding