Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Zahra Sabahi; Mohammad Javad Khoshnoud; Sara Hosseini; Fatemeh Khoshraftar; Marzieh Rashedinia

doi:10.1155/2021/5018092

Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Adv Pharmacol Pharm Sci. 2021 Dec 28:2021:5018092. doi: 10.1155/2021/5018092. eCollection 2021.

Authors

Zahra Sabahi¹, Mohammad Javad Khoshnoud^{2

3}, Sara Hosseini³, Fatemeh Khoshraftar³, Marzieh Rashedinia^{1

2

3}

Affiliations

¹ Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
² Food and Supplements Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
³ Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Objectives: Diabetic cardiomyopathy (DC) has become one of the serious complications in diabetic cases. In this study, we aimed to explore the syringic acid (SYR) protective effect against diabetes-induced cardiac injury in experimental rats.

Methods: Rats were divided in control and streptozotocin-induced diabetic rats which were subdivided into diabetic controls, and three test groups (SYR at 25, 50, and 100 mg/kg) and the nondiabetic group received 100 mg/kg of SYR. All treatments were given SYR for 6 weeks. SYR effects on cardiac diagnostic markers, heart lipid peroxidation, protein carbonylation, antioxidant system, and changes of the heart mitochondrial mass and biogenesis were measured.

Results: Diabetes induction prompted CK-MB, LDH levels in serum, cardiac catalase, and superoxide dismutase activity, as well as cardiac TBARs and carbonylated protein. SYR administration (100 m/kg) attenuated CK-MB and LDH levels. Also, 50 and 100 mg/kg of SYR reduced cardiac TBARs and carbonylated protein in diabetic rats. These treatments did not show any effects on GSH content, mtDNA, and mitochondrial biogenesis indices (PGC1- α, NRF1, NRF2, and TFAM) in heart tissue.

Conclusions: SYR treatment showed protective effects on diabetic cardiomyopathy in rats by reducing lipid peroxidation and protein carbonylation. The possible mechanisms could be related to antioxidant activity of this phenolic acid. SYR might play a role of a protective factor in cardiac challenges in diabetes.