Blood caspase-8 concentrations and mortality among septic patients

Abstract

Objective: No data are available on blood caspase-8 concentrations (the initiator caspase in the extrinsic apoptosis pathway) in septic patients. The present study thus describes the blood caspase-8 concentrations in survivors and non-survivors, and examines the possible association between blood caspase-8 concentrations and mortality in septic patients.

Design: A prospective observational study was carried out.

Setting: Three Spanish Intensive Care Units.

Patients: Septic patients.

Interventions: Serum caspase-8 concentrations were determined at the diagnosis of sepsis.

Main variable of interest: Mortality after 30 days.

Results: Patients not surviving at day 30 (n=81) compared to surviving patients (n=140) showed higher serum caspase-8 levels (p<0.001). Multiple logistic regression analysis found an association between serum caspase-8 levels>43.5ng/ml and mortality (OR=3.306; 95%CI=1.619-6.753; p=0.001). The area under the curve (AUC) for mortality predicted by serum caspase-8 levels was 67% (95% CI=60-73%; p<0.001).

Conclusions: The novel findings of our study were that blood caspase-8 concentrations are higher in non-survivors than in survivors, and that there is an association between blood caspase-8 concentrations and mortality in septic patients.

Keywords: Apoptosis; Caspasa-8; Caspase-8; Mortalidad; Mortality; Outcome; Resultado; Sepsis.