Abstract
Fever, hypotension, pulmonary infiltrates, and hypoxemia developed upon re-exposure to trimethoprim-sulfamethoxazole in 2 patients with the Acquired Immunodeficiency Syndrome. This reaction can mimic sepsis or the clinical worsening of underlying pulmonary opportunistic infection. The literature concerning adverse pulmonary effects of trimethoprim-sulfamethoxazole is reviewed.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications*
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Acquired Immunodeficiency Syndrome / drug therapy
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Adult
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Drug Combinations / adverse effects
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Exudates and Transudates / drug effects*
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Humans
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Hypoxia / chemically induced*
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Lung / drug effects*
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Male
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Middle Aged
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Opportunistic Infections / complications
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Opportunistic Infections / drug therapy
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Pneumonia, Pneumocystis / complications
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Pneumonia, Pneumocystis / drug therapy
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Sulfamethizole / adverse effects*
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Sulfathiazoles / adverse effects*
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Trimethoprim / adverse effects*
Substances
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Drug Combinations
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Sulfathiazoles
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Sulfamethizole
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trimethoprim sulfamethizole
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Trimethoprim