Cassane-type diterpenes from roots of Pterolobium macropterum and their anti-inflammatory activity

Phytochemistry. 2022 Apr:196:113074. doi: 10.1016/j.phytochem.2021.113074. Epub 2022 Jan 3.

Abstract

Eight undescribed cassane diterpenes, pterolobirins C-J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by single-crystal X-ray diffraction data. The compounds were screened for their anti-inflammatory activity on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in J774. A1 macrophage cells. Pterolobirin E and sucutinirane C displayed good NO inhibition with IC50 values of 24.44 ± 1.34 and 19.16 ± 1.22 μM, respectively.

Keywords: Cassane diterpenes; Leguminosae; Nitric oxide production; Pterolobirins; Pterolobium macropterum.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Caesalpinia* / chemistry
  • Diterpenes* / chemistry
  • Diterpenes* / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Nitric Oxide

Substances

  • Anti-Inflammatory Agents
  • Diterpenes
  • Nitric Oxide