The developmental roots of neurodegeneration

Morgan C Stephens; Vicky Brandt; Juan Botas

doi:10.1016/j.neuron.2021.12.004

The developmental roots of neurodegeneration

Neuron. 2022 Jan 5;110(1):1-3. doi: 10.1016/j.neuron.2021.12.004.

Authors

Morgan C Stephens¹, Vicky Brandt², Juan Botas³

Affiliations

¹ Department of Human and Molecular Genetics, Genetics & Genomics Graduate Program, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
² Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
³ Department of Human and Molecular Genetics, Genetics & Genomics Graduate Program, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA. Electronic address: jbotas@bcm.edu.

PMID: 34990574
DOI: 10.1016/j.neuron.2021.12.004

Abstract

Neurodegenerative disorders can alter neural circuitry long before symptoms appear, but the path from early changes to later pathologies is obscure. In this issue of Neuron, Capizzi et al. (2021) show how early axonal growth defects in Huntington's disease create vulnerability to later degeneration.

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MeSH terms

Humans
Huntington Disease* / pathology
Neurodegenerative Diseases* / pathology
Neurons / physiology