Halogen bonding organocatalysis enhanced through intramolecular hydrogen bonds

Chem Commun (Camb). 2022 Jan 27;58(9):1378-1381. doi: 10.1039/d1cc05475a.

Abstract

Recent results indicate a halogen bond donor is strengthened through direct interaction with a hydrogen bond to the electron-rich belt of the halogen. Here, this Hydrogen Bond enhanced Halogen Bond (HBeXB) plays a clear role in a catalyst. Our HBeXB catalyst improves product conversion in a halide abstraction reaction over a traditional halogen bonding derivative.