Ferroptosis-Inducing Nanomedicine for Cancer Therapy

Yang Wang; Tianfu Liu; Xiang Li; Hui Sheng; Xiaowen Ma; Liang Hao

doi:10.3389/fphar.2021.735965

Ferroptosis-Inducing Nanomedicine for Cancer Therapy

Front Pharmacol. 2021 Dec 20:12:735965. doi: 10.3389/fphar.2021.735965. eCollection 2021.

Authors

Yang Wang^{1

2

3}, Tianfu Liu^{1

2

3

4}, Xiang Li^{1

2

3

5}, Hui Sheng⁶, Xiaowen Ma^{1

2

3

7}, Liang Hao^{1

2

3

8}

Affiliations

¹ Department of Chemistry, School of Forensic Medicine, China Medical University, Shenyang, China.
² Key Laboratory of Forensic Bio-evidence Sciences, Shenyang, China.
³ China Medical University Center of Forensic Investigation, Shenyang, China.
⁴ China Medical University-The Queen's University of Belfast Joint College, China Medical University, Shenyang, China.
⁵ First Department of Clinical Medicine, China Medical University, Shenyang, China.
⁶ Physical College, Liaoning University, Shenyang, China.
⁷ Second Department of Clinical Medicine, China Medical University, Shenyang, China.
⁸ Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China.

Abstract

Ferroptosis, a new iron- and reactive oxygen species-dependent form of regulated cell death, has attracted much attention in the therapy of various types of tumors. With the development of nanomaterials, more and more evidence shows the potential of ferroptosis combined with nanomaterials for cancer therapy. Recently, there has been much effort to develop ferroptosis-inducing nanomedicine, specially combined with the conventional or emerging therapy. Therefore, it is necessary to outline the previous work on ferroptosis-inducing nanomedicine and clarify directions for improvement and application to cancer therapy in the future. In this review, we will comprehensively focus on the strategies of cancer therapy based on ferroptosis-inducing nanomedicine currently, elaborate on the design ideas of synthesis, analyze the advantages and limitations, and finally look forward to the future perspective on the emerging field.

Keywords: ROS; cancer therapy; combination strategies; ferroptosis; nanomedicine.

Publication types

Review