Dynamic hybrid-phase computed tomography simulation in lung stereotactic body radiotherapy: A feasibility study

Abstract

To assess the feasibility of dynamic hybrid-phase computed tomography (CT_DHP) simulation when patients undergo lung stereotactic body radiation therapy (SBRT). Eighteen non-small-cell lung-cancer patients were immobilised in a stereotactic body frame with abdominal compression. All underwent dynamic hybrid-phase CT scans that were compared with cone-beam CT (CBCT). We also determined the internal target volume (ITV) and evaluated the following four metrics: the "AND" function in the Boolean module of Eclipse, volume overlap (VO), Dice similarity coefficient (DSC), and dose-volume histogram. The average ITV values of 4DCT_DHP and 3D-CBCT were respectively 12.82±10.42 and 14.6±12.18 cm³ (n=72, p<0.001), and the average ITV value of AND was 11.7±10.1 cm³. The average planning target volume (PTV) of 4DCT_DHP and 3D-CBCT was 25.63±18.04 and 28.00±19.82 cm³ (n=72, p<0.001). The median AND difference between ITV and PTV was significant (p<0.01) and had a significantly linear distribution (R²=0.991 for ITV, R²=0.972 for PTV). The average VO of PTV was greater than that of ITV (0.81±0.096; 0.78±0.11). We also observed that the average DSC in PTV (0.83±0.066) was greater than that in ITV (0.81±0.084). The average results indicated that 97.9%±3.44 of ITV_CBCT was covered by 95% of the prescribed dose. The average minimum, maximum and mean percentage doses of ITV_CBCT were 87.9%±9.46, 107.3%±1.57, and 101.3%±1.12, respectively. This paper has demonstrated that dynamic hybrid-phase CT simulation for patients undergoing lung SBRT and also published evaluation metrics in scientific analysis. Our approach also has the advantage of adequate margin and fewer phases in CT simulation.

Keywords: CBCT; Dice similarity coefficient; ITV; SBRT.