COVID-19 and the Human Eye: Conjunctivitis, a Lone COVID-19 Finding - A Case-Control Study

Med Princ Pract. 2022;31(1):66-73. doi: 10.1159/000521808. Epub 2022 Jan 5.

Abstract

Objectives: COVID-19 has varied clinical manifestations, from asymptomatic to severe cases, and conjunctivitis is one of them, but sometimes a lone initial symptom is found to be present. The aim of this study was to identify the prevalence of conjunctivitis as the first symptom in COVID-19 patients in a primary healthcare unit.

Methodology: A retrospective study was conducted, analyzing the presenting complains/symptoms and results of COVID-19-confirmatory tests.

Results: Out of the 672 cases that were sent for RT-PCR testing, only 121 (18%) were found to be positive. Among these, 2.67% patients had both conjunctivitis and COVID-19, 77.77% patients had unilateral eye affected, while 22.22% had bilateral conjunctivitis of varying degrees. Fifteen patients diagnosed to have both acute conjunctivitis and COVID-19 presented other symptoms associated with COVID-19 infection. Three patients had only acute conjunctivitis during their entire course of COVID-19.

Conclusions: Conjunctivitis is a symptom of COVID-19 and may be the first sign of the infection, until the onset of the classical manifestations; such patients may continue to be a viral reservoir. Physicians should not miss unilateral conjunctivitis as it can be the only presenting complaint of COVID-19 during the initial phase, which might worsen if undetected and can aid in the spread of the contagion.

Keywords: Conjunctivitis; Corona virus disease-2019; Prevalence.

MeSH terms

  • Adult
  • COVID-19 / complications
  • COVID-19 / diagnosis*
  • COVID-19 / epidemiology
  • COVID-19 Nucleic Acid Testing
  • Case-Control Studies
  • Conjunctivitis / epidemiology*
  • Conjunctivitis / etiology
  • Eye / virology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • RNA, Viral / analysis*
  • Retrospective Studies
  • SARS-CoV-2
  • Young Adult

Substances

  • RNA, Viral