Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities

Xin Li; Jacky Man Chun Chan; Bosco Lam; David Christopher Lung; Kwok Cheung Lung; Christina Kin Yi Chow; Tracey Tam; Kelvin Hei Yeung Chiu; Ling Lung Hung; Ivan Fan Ngai Hung; Vincent Chi Chung Cheng; Kelvin Kai Wang To; Kwok Yung Yuen

doi:10.1093/cid/ciab1062

Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities

Clin Infect Dis. 2022 Aug 24;75(1):e905-e908. doi: 10.1093/cid/ciab1062.

Authors

Xin Li^{1

2}, Jacky Man Chun Chan³, Bosco Lam⁴, David Christopher Lung^{5

6}, Kwok Cheung Lung⁷, Christina Kin Yi Chow⁵, Tracey Tam⁸, Kelvin Hei Yeung Chiu², Ling Lung Hung², Ivan Fan Ngai Hung⁹, Vincent Chi Chung Cheng², Kelvin Kai Wang To^{1

2}, Kwok Yung Yuen^{1

2}

Affiliations

¹ State Key Laboratory for Emerging Infection Disease, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
² Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.
³ Department of Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁴ Department of Microbiology, Princess Margaret Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁵ Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁶ Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁷ Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁸ Quality & Safety Division, Hospital Authority, Hong Kong Special Administrative Region, People's Republic of Chinaand.
⁹ Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.

Abstract

This retrospective study of incoming travelers with coronavirus disease 2019 showed that individuals immunized by messenger RNA vaccines had significantly longer postvaccination intervals (median, 30.5 days) to breakthrough infection, lower white blood cell counts and lactate dehydrogenase levels on admission, and fewer radiographic abnormalities than those immunized by inactivated virus vaccine, who paradoxically had lower respiratory viral load.

Keywords: COVID-19; inactivated whole-virus vaccine; mRNA vaccine; vaccine breakthrough infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 Vaccines
COVID-19* / prevention & control
Humans
RNA, Messenger
Retrospective Studies
Vaccines, Inactivated
Viral Vaccines*
mRNA Vaccines

Substances

COVID-19 Vaccines
RNA, Messenger
Vaccines, Inactivated
Viral Vaccines
mRNA Vaccines