The PIKK-AKT connection in the DNA damage response

Sci Signal. 2022 Jan 4;15(715):eabm6211. doi: 10.1126/scisignal.abm6211. Epub 2022 Jan 4.

Abstract

DNA damage and subsequent cellular response are the basis for many cancer treatments. In this issue of Science Signaling, Liu et al. elucidate a mechanism by which cancer cells survive DNA damage induced by radiation and chemotherapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • DNA Damage*
  • Proto-Oncogene Proteins c-akt* / genetics
  • Proto-Oncogene Proteins c-akt* / metabolism
  • Signal Transduction

Substances

  • Proto-Oncogene Proteins c-akt