Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators

Menghan Niu; Xin Yang; Yuanyuan Li; Yanping Sun; Long Wang; Jing Ha; Yinghua Xie; Zibin Gao; Changzheng Tian; Le Wang; Yongjun Sun

doi:10.1007/s10571-021-01185-1

Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators

Cell Mol Neurobiol. 2023 Jan;43(1):139-153. doi: 10.1007/s10571-021-01185-1. Epub 2022 Jan 3.

Authors

Menghan Niu¹, Xin Yang^{2

3}, Yuanyuan Li¹, Yanping Sun^{1

4

5}, Long Wang⁶, Jing Ha¹, Yinghua Xie¹, Zibin Gao^{1

4

5}, Changzheng Tian⁷, Le Wang^{8

9}, Yongjun Sun^{10

11

12}

Affiliations

¹ Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.
² Department of Pharmaceutical Engineering, Hebei Chemical & Pharmaceutical College, Fangxing Road 88, Shijiazhuang, 050026, Hebei, China.
³ Hebei Technological Innovation Center of Chiral Medicine, Shijiazhuang, China.
⁴ Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, China.
⁵ State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, China.
⁶ Department of Family and Consumer Sciences, California State University, Long Beach, USA.
⁷ Department of Anesthesiology, The First Hospital of Hebei Medical University, Donggang Road 89, Shijiazhuang, 050000, Hebei, China. 409025167@qq.com.
⁸ Department of Pharmaceutical Engineering, Hebei Chemical & Pharmaceutical College, Fangxing Road 88, Shijiazhuang, 050026, Hebei, China. wangle58@163.com.
⁹ Hebei Technological Innovation Center of Chiral Medicine, Shijiazhuang, China. wangle58@163.com.
¹⁰ Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China. sunyongjun@hebust.edu.cn.
¹¹ Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, China. sunyongjun@hebust.edu.cn.
¹² State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, China. sunyongjun@hebust.edu.cn.

PMID: 34978648
DOI: 10.1007/s10571-021-01185-1

Abstract

NMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit composition, GluN2A-containing NMDA receptors can be divided into two types: diheteromeric and triheteromeric receptors. In this review, the expression, functional and pharmacological properties of different kinds of GluN2A-containing NMDA receptors as well as selective GluN2A regulators were described to further understand this type of NMDA receptors.

Keywords: Expression; Function properties GluN2A-selective regulators; GluN2A-containing NMDA receptors.

Publication types

Review

MeSH terms

Excitatory Amino Acid Antagonists / pharmacology
Neuronal Plasticity*
Receptors, N-Methyl-D-Aspartate* / metabolism

Substances

Receptors, N-Methyl-D-Aspartate
Excitatory Amino Acid Antagonists

Abstract

Publication types

MeSH terms

Substances

Grants and funding