Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

Weiting Liu; Zezhen Wu; Dan Zhu; Genben Chen; Guiming Yan; Shuo Zhang; Fengwu Chen; Barkat Ali Khan; Kaijian Hou

doi:10.3389/fmolb.2021.799934

Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

Front Mol Biosci. 2021 Dec 17:8:799934. doi: 10.3389/fmolb.2021.799934. eCollection 2021.

Authors

Weiting Liu¹, Zezhen Wu^{2

3}, Dan Zhu³, Genben Chen⁴, Guiming Yan¹, Shuo Zhang^{2

3}, Fengwu Chen^{3

5}, Barkat Ali Khan⁶, Kaijian Hou^{2

3}

Affiliations

¹ School of Nursing, Anhui University of Chinese Medicine, Hefei, China.
² The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
³ Department of Endocrine and Metabolic Diseases, Longhu People's Hospital, Shantou, China.
⁴ Department of Endocrine and Metabolic Diseases, Chaoan District People's Hospital, Chaozhou, China.
⁵ Department of Endocrine and Metabolic Diseases, the First Affiliated Hospital of Medical College of Shantou University, Shantou, China.
⁶ Drug Delivery and Cosmetics Lab (DDCL), GCPS, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.

Abstract

Background and Aim: It is known that hyperlipidemia and low vitamin D level are risk factors associated with cardiovascular disease (CVD). However, the effect of vitamin D administration on lipid profiles in postmenopausal women remains unclear. This study aims to evaluate the effect of vitamin D on lipid profiles in postmenopausal women based on meta-analysis and systemic review. Methods: The literature search was performed in multiple databases (Scopus, PubMed/Medline, Web of Science, and Embase) from 1997 to 2021. The statistical analysis was performed using the Stata software version 14 (Stata Corp. College Station, Texas, United States). The effects of vitamin D administration of the lipid profiles, including Triacylglycerol (TG), LDL-Cholesterol (LDL-C), HDL-Cholesterol (HDL-C), and Total Cholesterol (TC) were evaluated by the Der Simonian and Laird random effects model. The weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated. Results: The level of TG changed significantly by -3.76 mg/dl (CI: -6.12 to -1.39, p = 0.004) and HDL-C by 0.48 mg/dl (CI: -0.80 to -0.15, p = 0.004) in vitamin D administration group [11 eligible trials (placebo = 505 participants, vitamin D intervention = 604 participants)] compared to the control group in the postmenopausal women. Taking into account this comparison between groups, in contrast, the level of LDL-Cholesterol (LDL-C) (WMD: 0.73 mg/dl, 95% CI: -1.88, 3.36, p = 0.583) and TC (WMD: 0.689 mg/dl, CI: -3.059 to 4.438, p = 0.719) did not change significantly. Conclusion: In conclusion, the vitamin D administration in postmenopausal women, decreased the concentrations of TG, and HDL-C, but have no effects on LDL-C and TC.

Keywords: HDL; LDL; lipid profile; triglycerides; vitamin D.

Publication types

Review