Sickle cell hepatopathy is an underreported entity lacking clear management guidelines. This case highlights the potential role of hydroxyurea (HU) in improving the hepatic dysfunction seen among patients with sickle cell disease (SCD). We herein present the clinical course of a patient prior to and after the initiation of hydroxyurea with an emphasis on long-term outcomes and the patterns of liver injury over a 15-year time course.
Keywords: exchange blood transfusions; hydroxyurea; sickle cell disease; sickle cell intrahepatic cholestasis; sickle hepatopathy.
Copyright © 2021, Safhi et al.