Stability and surface properties of selenium nanoparticles coated with chitosan and sodium carboxymethyl cellulose

Yuying Chen; Serge Stoll; Hongbo Sun; Xinnan Liu; Wei Liu; Xiaojing Leng

doi:10.1016/j.carbpol.2021.118859

Stability and surface properties of selenium nanoparticles coated with chitosan and sodium carboxymethyl cellulose

Carbohydr Polym. 2022 Feb 15:278:118859. doi: 10.1016/j.carbpol.2021.118859. Epub 2021 Nov 4.

Authors

Yuying Chen¹, Serge Stoll², Hongbo Sun³, Xinnan Liu³, Wei Liu⁴, Xiaojing Leng⁵

Affiliations

¹ Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, China Agricultural University, Beijing 100083, China. Electronic address: chenyuxiaoying@163.com.
² Department F. A. Forel for Environmental and Aquatic Sciences, Section of Earth and Environmental Sciences and Institute for Environmental Sciences, University of Geneva, Carl-Vogt 66, CH-1211 Geneva, Switzerland. Electronic address: Serge.Stoll@unige.ch.
³ Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, China Agricultural University, Beijing 100083, China.
⁴ Department F. A. Forel for Environmental and Aquatic Sciences, Section of Earth and Environmental Sciences and Institute for Environmental Sciences, University of Geneva, Carl-Vogt 66, CH-1211 Geneva, Switzerland. Electronic address: Wei.Liu@unige.ch.
⁵ Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, China Agricultural University, Beijing 100083, China. Electronic address: lengxiaojingcau@163.com.

PMID: 34973724
DOI: 10.1016/j.carbpol.2021.118859

Abstract

The effect of polysaccharide coatings on the stability and release characteristics of selenium nanoparticles (SeNPs) was evaluated by comparing the characteristics of chitosan-coated SeNPs (CS-SeNPs) and sodium carboxymethyl cellulose-coated SeNPs (CMC-SeNPs). The release characteristics of SeNPs were investigated in storage conditions, gastrointestinal conditions, and free radical systems. CMC-SeNPs formed dimers or trimers, whereas CS-SeNPs were monodispersed but formed large aggregates in a pH range of 7.4-8.25. Upon 50 days of storage at 30 °C, both CMC-SeNPs and CS-SeNPs were converted to Se⁴⁺. SeNPs exhibited a lower release rate in simulated gastrointestinal conditions than in free radical systems. SeNPs release in ABTS and superoxide anion free radical systems followed the first-order and Korsmeyer-Peppas models, respectively, indicating that SeNP release is mainly governed by dissolution mechanisms. Additional studies are needed to examine the potential environmental effects and biological activity of the Se⁴⁺ released from SeNPs.

Keywords: Carboxymethyl cellulose; Chitosan; Free radical; Release mechanism; Selenium nanoparticles; Storage.

MeSH terms

Carboxymethylcellulose Sodium / chemistry*
Chitosan / chemistry*
Coated Materials, Biocompatible / chemical synthesis
Coated Materials, Biocompatible / chemistry*
Hydrodynamics
Nanoparticles / chemistry*
Particle Size
Selenium / chemistry*
Surface Properties

Substances

Coated Materials, Biocompatible
Chitosan
Selenium
Carboxymethylcellulose Sodium