Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment

Kang Fu; Yue Hu; Hui Zhang; Chen Wang; Zongwei Lin; Huixia Lu; Xiaoping Ji

doi:10.3389/fcvm.2021.760152

Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment

Front Cardiovasc Med. 2021 Dec 14:8:760152. doi: 10.3389/fcvm.2021.760152. eCollection 2021.

Authors

Kang Fu¹, Yue Hu¹, Hui Zhang¹, Chen Wang¹, Zongwei Lin¹, Huixia Lu¹, Xiaoping Ji¹

Affiliation

¹ The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China.

Abstract

Type-1 cardiorenal syndrome refers to acute kidney injury induced by acute worsening cardiac function. Worsening renal function is a strong and independent predictive factor for poor prognosis. Currently, several problems of the type-1 cardiorenal syndrome have not been fully elucidated. The pathogenesis mechanism of renal dysfunction is unclear. Besides, the diagnostic efficiency, sensitivity, and specificity of the existing biomarkers are doubtful. Furthermore, the renal safety of the therapeutic strategies for acute heart failure (AHF) is still ambiguous. Based on these issues, we systematically summarized and depicted the research actualities and predicaments of the pathogenesis, diagnostic markers, and therapeutic strategies of worsening renal function in type-1 cardiorenal syndrome.

Keywords: acute heart failure; biomarker; pathogenesis; treatment; type 1 cardiorenal syndrome; worsening renal function.

Publication types

Review