Electrostatically self-assembled filamentous sodium alginate/ε-polylysine fiber with antibacterial, bioadhesion and biocompatible in suturing wound

Xin Huang; Huijuan Jing; Xiaojing Du; Li Wang; Xingran Kou; Zhonghua Liu; Shijia Wu; Hongxin Wang

doi:10.1016/j.ijbiomac.2021.12.133

Electrostatically self-assembled filamentous sodium alginate/ε-polylysine fiber with antibacterial, bioadhesion and biocompatible in suturing wound

Int J Biol Macromol. 2022 Mar 1:200:1-11. doi: 10.1016/j.ijbiomac.2021.12.133. Epub 2021 Dec 27.

Authors

Xin Huang¹, Huijuan Jing², Xiaojing Du², Li Wang², Xingran Kou³, Zhonghua Liu⁴, Shijia Wu⁵, Hongxin Wang⁶

Affiliations

¹ The State Key Laboratory of Food Science & Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Perfume and Aroma Technology, Shanghai Insititue of Technology, Shanghai 201418, China.
² The State Key Laboratory of Food Science & Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
³ School of Perfume and Aroma Technology, Shanghai Insititue of Technology, Shanghai 201418, China.
⁴ College of Horticulture, Hu'nan Agricultural University, Changsha, Hunan 410128, China.
⁵ The State Key Laboratory of Food Science & Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: wusj1986@163.com.
⁶ The State Key Laboratory of Food Science & Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: hxwang@jiangnan.edu.cn.

PMID: 34968544
DOI: 10.1016/j.ijbiomac.2021.12.133

Abstract

In the work, a novel filamentou sodium alginate (SA) /ε-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte ε-PL and anionic natural polysaccharide SA. The SA/PL fiber exhibits good antibacterial activity, low cytotoxicity, anti-hemolysis, bioadhesion, and environmental friendliness due to its natural raw materials and green preparation process. In vivo experiments have shown that the SA/PL fiber can promote the healing and repair of skin wounds on the backs of mice via resistance to pathogen infection, reduction of inflammation, and anti-allogeneic allergy of the wound. In summary, these results demonstrate that the SA/PL fiber is a green and biosafe multifunctional natural polymer material, with potential applications in suturing wound.

Keywords: Antibacterial; Bioadhesion; Biocompatible; Electrostatic self-assembly; Sodium alginate/ε-polylysine fiber.

MeSH terms

Alginates*
Polylysine / analogs & derivatives*

Substances

Alginates
alginate-polylysine-alginate
Polylysine