Cellular Deubiquitylating Enzyme: A Regulatory Factor of Antiviral Innate Immunity

Sijing Long; Li Yang; Wei Dang; Shuyu Xin; Mingjuan Jiang; Wentao Zhang; Jing Li; Yiwei Wang; Senmiao Zhang; Jianhong Lu

doi:10.3389/fmicb.2021.805223

Cellular Deubiquitylating Enzyme: A Regulatory Factor of Antiviral Innate Immunity

Front Microbiol. 2021 Dec 13:12:805223. doi: 10.3389/fmicb.2021.805223. eCollection 2021.

Authors

Sijing Long^{1

2

3

4}, Li Yang^{1

2

3

4}, Wei Dang^{1

2

3

4}, Shuyu Xin^{1

2

3

4}, Mingjuan Jiang^{1

2

3

4}, Wentao Zhang^{1

2

3

4}, Jing Li^{1

2

3

4}, Yiwei Wang^{1

2

3

4}, Senmiao Zhang^{1

2

3

4}, Jianhong Lu^{1

2

3

4}

Affiliations

¹ Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
² Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China.
³ NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China.
⁴ China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China.

Abstract

Deubiquitylating enzymes (DUBs) are proteases that crack the ubiquitin code from ubiquitylated substrates to reverse the fate of substrate proteins. Recently, DUBs have been found to mediate various cellular biological functions, including antiviral innate immune response mediated by pattern-recognition receptors (PRRs) and NLR Family pyrin domain containing 3 (NLRP3) inflammasomes. So far, many DUBs have been identified to exert a distinct function in fine-tuning antiviral innate immunity and are utilized by viruses for immune evasion. Here, the recent advances in the regulation of antiviral responses by DUBs are reviewed. We also discussed the DUBs-mediated interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antiviral innate immunity. The understanding of the mechanisms on antiviral innate immunity regulated by DUBs may provide therapeutic opportunities for viral infection.

Keywords: SARS-CoV-2; deubiquitylating enzymes; immune evasion; inflammasome; innate immunity; pattern-recognition receptors; virus.

Publication types

Review