Pediatric Acute Lymphoblastic Leukemia With Hypereosinophilia and IDH2 Gene Mutation: A Case Report and Literature Review

J Pediatr Hematol Oncol. 2022 Mar 1;44(2):e546-e549. doi: 10.1097/MPH.0000000000002375.

Abstract

Eosinophilia is a rare presentation of acute lymphoblastic leukemia (ALL) within the pediatric population. In this report, we present a patient with pre-B ALL and eosinophilia in the setting of an isocitrate dehydrogenase-2 gene mutation. These mutations have been described in patients with acute myeloid leukemia but in very few patients with ALL.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child
  • Eosinophilia* / genetics
  • Humans
  • Isocitrate Dehydrogenase / genetics
  • Leukemia, Myeloid, Acute* / genetics
  • Mutation
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics

Substances

  • Isocitrate Dehydrogenase