Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

G Ryan Crislip; Jermaine G Johnston; Lauren G Douma; Hannah M Costello; Alexandria Juffre; Kyla Boyd; Wendy Li; Cheoting C Maugans; Miguel Gutierrez-Monreal; Karyn A Esser; Andrew J Bryant; Andrew C Liu; Michelle L Gumz

doi:10.1002/cphy.c210011

Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

Compr Physiol. 2021 Dec 29;12(1):2769-2798. doi: 10.1002/cphy.c210011.

Authors

G Ryan Crislip¹, Jermaine G Johnston², Lauren G Douma³, Hannah M Costello¹, Alexandria Juffre³, Kyla Boyd³, Wendy Li³, Cheoting C Maugans³, Miguel Gutierrez-Monreal¹, Karyn A Esser^{1

4}, Andrew J Bryant⁵, Andrew C Liu^{1

4}, Michelle L Gumz^{2

3

1

6}

Affiliations

¹ Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA.
² Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USA.
³ Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
⁴ Myology Institute, University of Florida, Gainesville, Florida, USA.
⁵ Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, Florida, USA.
⁶ Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, Gainesville, Florida, USA.

PMID: 34964116
DOI: 10.1002/cphy.c210011

Abstract

Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of physiological systems is associated with pathophysiological disorders. Here, we review the current understanding of the molecular mechanisms contributing to the known circadian rhythms in physiological function. This article focuses on what is known in humans, along with discoveries made with cell and rodent models. In particular, the impact of circadian clock components in metabolic, cardiovascular, endocrine, musculoskeletal, immune, and central nervous systems are discussed. © 2021 American Physiological Society. Compr Physiol 11:1-30, 2021.

Publication types

Review

MeSH terms

Animals
Circadian Clocks* / genetics
Circadian Rhythm* / physiology
Endocrine System
Homeostasis
Humans
Mammals

Abstract

Publication types

MeSH terms

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