Current Take on Systemic Sclerosis Patients' Vaccination Recommendations

Giuseppe Murdaca; Giovanni Noberasco; Dario Olobardi; Claudio Lunardi; Matteo Maule; Lorenzo Delfino; Massimo Triggiani; Chiara Cardamone; Devis Benfaremo; Gianluca Moroncini; Angelo Vacca; Nicola Susca; Sebastiano Gangemi; Paola Quattrocchi; Laura Sticchi; Giancarlo Icardi; Andrea Orsi

doi:10.3390/vaccines9121426

Current Take on Systemic Sclerosis Patients' Vaccination Recommendations

Vaccines (Basel). 2021 Dec 2;9(12):1426. doi: 10.3390/vaccines9121426.

Authors

Giuseppe Murdaca¹, Giovanni Noberasco², Dario Olobardi², Claudio Lunardi³, Matteo Maule³, Lorenzo Delfino³, Massimo Triggiani⁴, Chiara Cardamone⁴, Devis Benfaremo^{5

6}, Gianluca Moroncini^{5

6}, Angelo Vacca⁷, Nicola Susca⁷, Sebastiano Gangemi⁸, Paola Quattrocchi⁸, Laura Sticchi^{2

9}, Giancarlo Icardi^{2

9}, Andrea Orsi^{2

9}

Affiliations

¹ Departments of Internal Medicine, University of Genova, 16132 Genova, Italy.
² Department of Health Sciences, University of Genova, 16132 Genova, Italy.
³ Department of Medicine, University of Verona, 37129 Verona, Italy.
⁴ Division of Allergy and Clinical Immunology, University of Salerno, 84084 Salerno, Italy.
⁵ Clinica Medica, Ospedali Riuniti Ancona, 60126 Ancona, Italy.
⁶ Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, 60126 Ancona, Italy.
⁷ "Guido Baccelli" Unit of Internal Medicine, Department of Biomedical Sciences and Human Oncology, School of Medicine, Aldo Moro University of Bari, 70121 Bari, Italy.
⁸ Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98124 Messina, Italy.
⁹ Hygiene Unit, "Ospedale Policlinico San Martino IRCCS", 16132 Genova, Italy.

Abstract

Systemic sclerosis (SSc) is a rare autoimmune inflammatory rheumatic disease. The prevalence of SSc ranges from 7 to 700 cases per million worldwide. Due to multiple organ involvement and constant inflammatory state, this group of patients presents an increased risk of infectious diseases. This paper aimed to gather the up-to-date evidence on vaccination strategies for patients with SSc and to be a useful tool for the prevention and management of infectious diseases. The authors conducted a scoping review in which each paragraph presents data on a specific vaccine's safety, immunogenicity, and efficacy. The work deals with the following topics: SARS-CoV-2, seasonal influenza, S. pneumoniae, HAV, HBV, HZV, N. meningitidis, H. influenzae, HPV, and diphtheria-tetanus-pertussis.

Keywords: H. influenzae; HPV; HZV; N. meningitidis; S. pneumoniae; SARS-CoV-2; diphtheria-tetanus-pertussis; hepatitis; influenza; systemic sclerosis.

Publication types

Review