Body Composition and Its Impact on the Hormonal Disturbances in Women with Polycystic Ovary Syndrome

Nutrients. 2021 Nov 24;13(12):4217. doi: 10.3390/nu13124217.

Abstract

We investigated the relationship between selected body composition (BC) parameters and included 55 women diagnosed with PCOS and 29 women in which PCOS was excluded. Hormone concentration and BC parameters were assessed during hospitalization. Women with PCOS had higher concentration of luteinizing hormones, total testosterone, androstenedione, and Anti-Müllerian hormones compared to women that were not diagnosed with PCOS. We did not observe any significant differences in the BC parameters between both groups as well as between four PCOS phenotype subgroups. Only in the group of women with PCOS was the concentration of sex hormone binding globulin and free testosterone correlated with all investigated BC parameters. Correspondence analysis did not confirm unambiguously associations between phenotypes of PCOS and the value of BC parameters, while logistic regression revealed that increased Anti-Müllerian hormone concentration and the value of body mass index could be useful parameters in differentiating women with PCOS and women with other disorders. The ROC analysis performed on the entire group of women also confirmed that the concentration of Anti-Müllerian hormones could be a powerful parameter to categorize women as suffering from PCOS.

Keywords: body composition; hormones; polycystic ovary syndrome.

MeSH terms

  • Adolescent
  • Adult
  • Androstenedione / blood
  • Anti-Mullerian Hormone / blood
  • Body Composition / physiology*
  • Body Mass Index
  • Case-Control Studies
  • Female
  • Follicle Stimulating Hormone / blood
  • Hormones / blood*
  • Humans
  • Luteinizing Hormone / blood
  • Phenotype
  • Polycystic Ovary Syndrome / blood
  • Polycystic Ovary Syndrome / physiopathology*
  • ROC Curve
  • Sex Hormone-Binding Globulin / analysis
  • Testosterone / blood
  • Young Adult

Substances

  • Hormones
  • SHBG protein, human
  • Sex Hormone-Binding Globulin
  • Testosterone
  • Androstenedione
  • Anti-Mullerian Hormone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone