Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System

Takako Kikkawa; Noriko Osumi

doi:10.3389/fnins.2021.789583

Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System

Front Neurosci. 2021 Dec 9:15:789583. doi: 10.3389/fnins.2021.789583. eCollection 2021.

Authors

Takako Kikkawa¹, Noriko Osumi¹

Affiliation

¹ Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Sendai, Japan.

Abstract

The Dmrt genes encode the transcription factor containing the DM (doublesex and mab-3) domain, an intertwined zinc finger-like DNA binding module. While Dmrt genes are mainly involved in the sexual development of various species, recent studies have revealed that Dmrt genes, which belong to the DmrtA subfamily, are differentially expressed in the embryonic brain and spinal cord and are essential for the development of the central nervous system. Herein, we summarize recent studies that reveal the multiple functions of the Dmrt genes in various aspects of vertebrate neural development, including brain patterning, neurogenesis, and the specification of neurons.

Keywords: DmrtA subfamily; corticogenesis; neurogenesis; neuronal specification; patterning.

Publication types

Review