Comparison of the QuantiFERON-TB® Gold Plus on LIAISON® XL and T-SPOT.TB for the diagnosis of latent Mycobacterium tuberculosis infection in a low tuberculosis incidence population

Diagn Microbiol Infect Dis. 2022 Mar;102(3):115613. doi: 10.1016/j.diagmicrobio.2021.115613. Epub 2021 Nov 29.

Abstract

The current study compared the QuantiFERON-TB® Gold Plus on LIAISON® XL to the T-SPOT.TB for the diagnosis of latent Mycobacterium tuberculosis infection on 125 patient samples. A high agreement of qualitative results (90%) was observed between both methods with 3% major discrepancies, half of which were false negative results with the T-SPOT.TB.

Keywords: Interferon-gamma release assay; Liaison® XL; Mycobacterium tuberculosis; QuantiFERON-TB Gold Plus; T-SPOT.TB.

MeSH terms

  • Gold
  • Humans
  • Incidence
  • Interferon-gamma Release Tests
  • Latent Tuberculosis* / diagnosis
  • Latent Tuberculosis* / epidemiology
  • Mycobacterium tuberculosis*
  • Tuberculin Test
  • Tuberculosis* / diagnosis
  • Tuberculosis* / epidemiology

Substances

  • Gold