A highly sensitive dual-readout assay for perfluorinated compounds based CdTe quantum dots

Fang Zhang; Jiaman Liang; Yang Liu; Qiuju Zhou; Yushuang Hong; Xianping Chen; Kejun Tan

doi:10.1016/j.saa.2021.120753

A highly sensitive dual-readout assay for perfluorinated compounds based CdTe quantum dots

Spectrochim Acta A Mol Biomol Spectrosc. 2022 Mar 15:269:120753. doi: 10.1016/j.saa.2021.120753. Epub 2021 Dec 14.

Authors

Fang Zhang¹, Jiaman Liang², Yang Liu³, Qiuju Zhou⁴, Yushuang Hong⁵, Xianping Chen⁵, Kejun Tan⁶

Affiliations

¹ Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China; College of Food Science and Engineering, Zhengzhou University of Science and Technology, Zhengzhou 450064, China.
² Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China; Ziyang food and drug inspection and Testing Center, Ziyang 641399, China.
³ Department of Chemical and Biological Engineering, The University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, United States.
⁴ Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address: zqq0707@swu.edu.cn.
⁵ Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
⁶ Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address: tankj@swu.edu.cn.

PMID: 34952440
DOI: 10.1016/j.saa.2021.120753

Abstract

Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate (PFOS) are two typical perfluorinated compounds (PFCs) that poss potential ecological toxicity. In this work, a fluorescence and resonance light scattering (RLS) dual-readout strategy for the detection of PFCs at picomole level based on the water-soluble CdTe quantum dots (CdTe QDs) has been proposed. It is found that the CdTe QDs exhibit a quenching in the presence of PFCs and thus serve as useful probes for PFCs. The linear ranges are 0.032-10.0 nM with a limit of detection(LOD) of 32.02 pM for PFOA and 0.044-15.0 nM with a LOD of 43.96 pM for PFOS, respectively. Meanwhile, PFCs can form complexes with CdTe QDs in acid medium, resulting in remarkable RLS signals. The enhanced RLS intensities are in proportion to the concentrations of PFOA and PFOS, respectively. And the linear ranges are 0.048-5.0 nM with a LOD of 47.78 pM for PFOA, and 0.057-5.0 nM with a LOD of 56.72 pM for PFOS, respectively. This dual-mode detection increases the reliability of the measurement. The proposed method is simple, sensitive and cost-effective, with potential applications in environmental monitoring and assessment.

Keywords: CdTe quantum dots; Fluorescence; Perfluorinated compounds; Picomole quantities; Resonance light scattering.

MeSH terms

Cadmium Compounds*
Quantum Dots*
Reproducibility of Results
Tellurium

Substances

Cadmium Compounds
Tellurium
cadmium telluride