Biocompatible BSA-Ag2S nanoparticles for photothermal therapy of cancer

Junwei Zhao; Qian Zhang; Wenquan Liu; Guiye Shan; Xin Wang

doi:10.1016/j.colsurfb.2021.112295

Biocompatible BSA-Ag₂S nanoparticles for photothermal therapy of cancer

Colloids Surf B Biointerfaces. 2022 Mar:211:112295. doi: 10.1016/j.colsurfb.2021.112295. Epub 2021 Dec 16.

Authors

Junwei Zhao¹, Qian Zhang², Wenquan Liu³, Guiye Shan⁴, Xin Wang⁵

Affiliations

¹ Henan Key Laboratory of Special Protective Materials, Materials Science and Engineering School, Luoyang Institute of Science and Technology, Luoyang 471023, PR China; CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, PR China.
² CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, PR China.
³ Henan Key Laboratory of Photovoltaic Materials, Henan University, Kaifeng 475004, PR China; Center for Advanced Optoelectronic Functional Materials Research, and Key Lab of UV-Emitting Materials and Technology of Ministry Education, Northeast Normal University, Changchun 130024, PR China.
⁴ Center for Advanced Optoelectronic Functional Materials Research, and Key Lab of UV-Emitting Materials and Technology of Ministry Education, Northeast Normal University, Changchun 130024, PR China.
⁵ Henan Key Laboratory of Photovoltaic Materials, Henan University, Kaifeng 475004, PR China; CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, PR China. Electronic address: xwang2008@vip.henu.edu.cn.

PMID: 34952286
DOI: 10.1016/j.colsurfb.2021.112295

Abstract

Photothermal therapy (PTT) induced by near-infrared (NIR) laser has attracted much attention for the innovation of tumor therapy, in which the photothermal agent with good biocompatibility and high efficiency is the prerequisite. Herein, the biocompatible bovine serum albumin (BSA) coated Ag₂S nanoparticles (NPs) as photothermal agent were synthesized directly at mild temperature for PTT of cancer. The high photothermal conversion efficiency of the obtained Ag₂S NPs with strong NIR absorption is about 18.89%, which make them ideal materials for photothermal agents. Furthermore, the Ag₂S NPs can induce effective apoptosis of tumor cells exposed to an NIR laser (808 nm), realizing an effective PTT with excellent killing effect of tumor cells. This work provides a simple reproducible method to fabricate the water-soluble and biocompatible Ag₂S NPs, which would provide new insights of designing new functional NPs for the PTT therapy of tumor.

Keywords: Ag(2)S; Biocompatible; Photothermal effect; Photothermal therapy; Water-soluble.

MeSH terms

Humans
Nanoparticles*
Neoplasms* / therapy
Phototherapy
Photothermal Therapy
Serum Albumin, Bovine

Substances

Serum Albumin, Bovine