The Value of a Systematic Protocol Using Endobronchial Ultrasound and Endoscopic Ultrasound in Staging of Lung Cancer for Patients with Imaging iN0-N1 Disease

Rosa Cordovilla; Marco López-Zubizarreta; Antonio Velasco; Alberto Álvarez; Marta Rodríguez; Asunción Gómez; Miguel Ángel Hernández-Mezquita; Miguel Iglesias

doi:10.1159/000519034

The Value of a Systematic Protocol Using Endobronchial Ultrasound and Endoscopic Ultrasound in Staging of Lung Cancer for Patients with Imaging iN0-N1 Disease

Biomed Hub. 2021 Oct 8;6(3):92-101. doi: 10.1159/000519034. eCollection 2021 Sep-Dec.

Authors

Rosa Cordovilla¹, Marco López-Zubizarreta¹, Antonio Velasco², Alberto Álvarez², Marta Rodríguez³, Asunción Gómez³, Miguel Ángel Hernández-Mezquita¹, Miguel Iglesias¹

Affiliations

¹ Interventional Pulmonology Unit, Pulmonary Department, Salamanca University Hospital, Salamanca, Spain.
² Gastroenterologist Department, Salamanca University Hospital, Salamanca, Spain.
³ Cytopathology Unit, Pathology Department, Salamanca University Hospital, Salamanca, Spain.

Abstract

Introduction: We hypothesize that systematic, combined, and multidisciplinary study of the mediastinum (endobronchial ultrasound [EBUS] and endoscopic ultrasound [EUS]) in patients with NSCLC with radiologically normal mediastinum improves the results of mediastinal staging obtained with EBUS alone.

Material and methods: A retrospective study of the prospective database collected on the patients with NSCLC with a radiologically normal mediastinum and an indication for systematic staging with EBUS and EUS. EBUS staging was followed by EUS in patients in which the results from the pathological analysis of EBUS were negative.

Results: Forty-five patients were included in the analysis. The combination of EBUS followed by EUS provided better results than EBUS alone: sensitivity (S) 95% versus 80%, negative predictive value (NPV) 96.15% versus 86.21%, negative likelihood ratio 0.05 versus 0.20, and post-test probability 3.8% versus 13.8%. This represents an increase in S (15%), the validity index (6.6%), and NPV (9.9%) compared to EBUS alone. There were 4 false negatives (FNs) (8.8%) with the EBUS test alone. After adding EUS, 3 more cases were positive (6.6%) and only 1 FN (2.2%).

Conclusions: In patients with NSCLC and a radiographically normal mediastinum, a systematic and combined staging with EBUS and EUS show higher sensitivity in the detection of mediastinal metastasis than with the use of EBUS alone. The high accuracy of the test means that the use of mediastinoscopy is not necessary to confirm the results in these patients. Since the availability of EUS is low, it may be advisable for the interventional pulmonologist to receive training in EUS-b.

Keywords: Endobronchial ultrasound; Endoscopic ultrasound; Lung cancer; Radiographically normal mediastinum; Staging.