Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review

Tito Brambullo; Gian Paolo Azzena; Paolo Toninello; Giuseppe Masciopinto; Alberto De Lazzari; Bernardo Biffoli; Vincenzo Vindigni; Franco Bassetto

doi:10.3389/fonc.2021.783257

Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review

Front Oncol. 2021 Dec 7:11:783257. doi: 10.3389/fonc.2021.783257. eCollection 2021.

Authors

Tito Brambullo¹, Gian Paolo Azzena¹, Paolo Toninello¹, Giuseppe Masciopinto¹, Alberto De Lazzari¹, Bernardo Biffoli¹, Vincenzo Vindigni¹, Franco Bassetto¹

Affiliation

¹ Clinic of Plastic Surgery, Department of Neurosciences, Padua University Hospital, Padua, Italy.

Abstract

Among the non-melanoma skin cancers (NMSC) the squamous cell carcinoma (SCC) is one of the most challenging for the surgeon. Local aggressiveness and a tendency to metastasize to regional lymph nodes characterize the biologic behavior. The variants locally advanced and metastatic require wide excision and node dissection. Such procedures can be extremely detrimental for patients. The limit of the surgery can be safely pushed forward with a multidisciplinary approach. The concept of skin oncoplastic surgery, the ablative procedures and the reconstructive options (skin graft, pedicled flap, microsurgical free flap) are discussed together with a literature review.

Keywords: SCC; locally advanced disease; microsurgery; non-melanoma skin cancer; oncoplastic; reconstructive surgery; skin oncoplastic surgery; squamous cell carcinoma.

Publication types

Review