Vitreous and Optic Nerve Infiltration of an Adrenal B Lymphoma

Lucía Galletero Pandelo; Cristina Rodríguez Vidal; Joseba Artaraz; Nerea Martínez-Alday; Alex Fonollosa

doi:10.1159/000520338

Vitreous and Optic Nerve Infiltration of an Adrenal B Lymphoma

Case Rep Ophthalmol. 2021 Nov 16;12(3):915-920. doi: 10.1159/000520338. eCollection 2021 Sep-Dec.

Authors

Lucía Galletero Pandelo¹, Cristina Rodríguez Vidal¹, Joseba Artaraz¹, Nerea Martínez-Alday¹, Alex Fonollosa^{1

2}

Affiliations

¹ Department of Ophthalmology, BioCruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Baracaldo, Spain.
² Bilbao Ophthalmological Institute, Bilbo, Spain.

Abstract

Aim: This study aimed to report a case of vitreous and optic nerve infiltration of a primary adrenal B lymphoma.

Case report: An 81-year-old patient consulted for decrease in vision in the left eye and pain with ocular movements during the last week. The patient was being treated with chemotherapy for an adrenal gland diffuse large B-cell lymphoma. On examination, vitritis was seen in both eyes and optic disc edema in his left eye. After an extensive study based on orbital and brain magnetic resonance imaging and vitreous cytology, an ocular infiltration by systemic B lymphoma was confirmed. A treatment based on intravitreal methotrexate was carried out, achieving the regression of the vitreous infiltration and resolution of the optic disc edema. Systemic B lymphoma metastasizing ocular structures is extremely infrequent. The manifestations may mimic an inflammatory disease. Ophthalmologists should be aware of these manifestations and consider among the masquerade syndromes.

Keywords: Lymphoma; Metastases; Methotrexate; Optic disc edema; Vitritis.

Publication types

Case Reports