Cycloserine did not increase depression incidence or severity at standard dosing for multidrug-resistant tuberculosis

Eur Respir J. 2022 Mar 24;59(3):2102511. doi: 10.1183/13993003.02511-2021. Print 2022 Mar.

Abstract

In a longitudinal cohort of MDR-TB patients receiving individualised, DST-based treatment, neither the inclusion of cycloserine in a multidrug regimen nor the dose used (up to 750 mg daily) significantly increased incidence of depression during treatment https://bit.ly/3GtQmOH

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Cycloserine*
  • Depression
  • Humans
  • Incidence
  • Tuberculosis, Multidrug-Resistant* / drug therapy
  • Tuberculosis, Multidrug-Resistant* / epidemiology

Substances

  • Antitubercular Agents
  • Cycloserine