Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms

Chrispin Chaguza; Marie Yang; Laura C Jacques; Stephen D Bentley; Aras Kadioglu

doi:10.1016/j.tim.2021.11.007

Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms

Trends Microbiol. 2022 Jun;30(6):581-592. doi: 10.1016/j.tim.2021.11.007. Epub 2021 Dec 20.

Authors

Chrispin Chaguza¹, Marie Yang², Laura C Jacques³, Stephen D Bentley⁴, Aras Kadioglu²

Affiliations

¹ Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Darwin College, University of Cambridge, Silver Street, Cambridge, UK; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK; NIHR Mucosal Pathogens Research Unit, Division of Infection and Immunity, University College London, London, UK. Electronic address: Chrispin.Chaguza@sanger.ac.uk.
² Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK.
³ Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK. Electronic address: ljacques@liverpool.ac.uk.
⁴ Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK.

Abstract

Streptococcus pneumoniae (the 'pneumococcus') is a significant cause of morbidity and mortality worldwide, causing life-threatening diseases such as pneumonia, bacteraemia, and meningitis, with an annual death burden of over one million. Discovered over a century ago, pneumococcal serotype 1 (S1) is a significant cause of these life-threatening diseases. Our understanding of the epidemiology and biology of pneumococcal S1 has significantly improved over the past two decades, informing the development of preventative and surveillance strategies. However, many questions remain unanswered. Here, we review the current state of knowledge of pneumococcal S1, with a special emphasis on clinical epidemiology, genomics, and disease mechanisms.

Keywords: genomics; invasiveness; outbreaks; pneumococcus; serotype 1; virulence.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Genomics
Humans
Pneumococcal Infections* / epidemiology
Serogroup
Streptococcus pneumoniae* / genetics

Abstract

Publication types

MeSH terms

Grants and funding