Physicians' Experience with COVID-19 Vaccination: A Survey Study

Alina Dima; Ciprian Jurcut; Daniel Vasile Balaban; Valeriu Gheorghita; Ruxandra Jurcut; Augustin Catalin Dima; Mariana Jinga

doi:10.3390/healthcare9121746

Physicians' Experience with COVID-19 Vaccination: A Survey Study

Healthcare (Basel). 2021 Dec 17;9(12):1746. doi: 10.3390/healthcare9121746.

Authors

Alina Dima¹, Ciprian Jurcut², Daniel Vasile Balaban^{2

3}, Valeriu Gheorghita^{2

3}, Ruxandra Jurcut^{3

4}, Augustin Catalin Dima², Mariana Jinga^{2

3}

Affiliations

¹ Department of Rheumatology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
² Central Military Emergency University Hospital Dr. Carol Davila, 010825 Bucharest, Romania.
³ Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
⁴ Department of Cardiology, Institute for Cardiovascular Diseases C.C. Iliescu, 022328 Bucharest, Romania.

Abstract

Background: COVID-19 vaccine hesitancy remains high in the general population and is the main determinant of low vaccination rates and of the fourth pandemic wave severity in Romania. Additional information is needed to raise awareness over vaccine efficiency and the safety profile.

Objective: To assess self-reported experience related to COVID-19 vaccination in Romanian physicians.

Design, setting, and participants: A cross-sectional, self-administered questionnaire-based survey, distributed online in the period 24 March to 24 May 2021. The survey included 30 cascade questions with skip logic filters. All physicians included filled in the questionnaire voluntarily and anonymously. Not all respondents filled in all questions. Main outcome and measure: Primary outcomes addressed were related to the COVID-19 vaccine safety profile.

Results: 407/467 (87.15%) of the respondents' physicians were fully vaccinated, mostly with the Pfizer-BioNTech (Comirnaty)-BNT162b2 vaccine, with the peak of immunization in January 2021, with almost four-fifths of the study participants. Regarding COVID-19, almost 20% physicians had the infection and one declared COVID-19 re-infection. A number of 48/420 (11.42%) and 47/419 (11.22%) of the vaccinated physicians did not report any side effects after the first or second vaccine dose. However, most of the side effects reported were minor. Only 50/360 (13.88%) physicians reported the vaccine side effects on the dedicated online national platform. Approximately 40% respondents checked the anti-spike SARS-CoV2 antibodies' titer after complete vaccination, of which two cases reported indeterminate levels. Lower anti-spike SARS-CoV2 antibodies' titer of 100-1000 times the laboratory limit was more frequent in naive physicians (36.95% versus 14.28%, p = 0.012), moderate titers were similar, while very high levels, more than 10,000 times laboratory limit, were more frequent in physicians with previous COVID-19 infection (2.17% versus 42.85%, p < 0.001).

Conclusions and relevance: In this cross-sectional survey study on the COVID-19 vaccination among Romanian physicians, we describe a safety vaccination profile among Romanian physicians.

Keywords: COVID-19; SARS-CoV2; coronavirus; vaccine hesitancy.