Evaluation of Toxoplasma gondii recombinant antigens for early diagnosis of congenital toxoplasmosis

Diagn Microbiol Infect Dis. 2022 Mar;102(3):115608. doi: 10.1016/j.diagmicrobio.2021.115608. Epub 2021 Nov 27.

Abstract

The performance of Toxoplasma rGra8, rMic1, and the chimeric rGra4-Gra7 antigens for early congenital toxoplasmosis (CT) diagnosis was evaluated. Sera from CT patients showed high IgG reactivity to rMic1, rGra8, and rGra4-Gra7. The seroreactivity of samples from uninfected infants was lost within 2 months of age.

Keywords: Congenital infection; Diagnosis; Recombinant antigen; Serology; Toxoplasmosis.

MeSH terms

  • Antibodies, Protozoan
  • Antigens, Protozoan / genetics
  • Early Diagnosis
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunoglobulin G
  • Infant
  • Sensitivity and Specificity
  • Toxoplasma* / genetics
  • Toxoplasmosis* / diagnosis
  • Toxoplasmosis, Congenital* / diagnosis

Substances

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Immunoglobulin G