1 Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands; Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. Electronic address: a.e.gorbalenya@lumc.nl.
2 Institute of Applied Simulation, Zurich University of Applied Sciences, ZHAW Wädenswil, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. Electronic address: anis@zhaw.ch.