Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031

Mar Drugs. 2021 Dec 10;19(12):701. doi: 10.3390/md19120701.

Abstract

Three novel cyclic hexapeptides, sclerotides C-E (1-3), and a new lipodepsipeptide, scopularide I (4), together with a known cyclic hexapeptide sclerotide A (5), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey's method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I (4) exhibited acetylcholinesterase inhibitory activity with an IC50 value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC50 value of 10.1 μM.

Keywords: AChE inhibitory; Aspergillus sclerotiorum; lipodepsipeptide; nasopharyngeal carcinoma; sclerotides.

MeSH terms

  • Acetylcholinesterase / drug effects
  • Animals
  • Anthozoa*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Aquatic Organisms
  • Aspergillus / chemistry*
  • Cell Line, Tumor / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Peptides, Cyclic
  • Acetylcholinesterase

Supplementary concepts

  • Aspergillus sclerotiorum