Discussion of Research Priorities for Gait Disorders in Parkinson's Disease

Nicolaas I Bohnen; Rui M Costa; William T Dauer; Stewart A Factor; Nir Giladi; Mark Hallett; Simon J G Lewis; Alice Nieuwboer; John G Nutt; Kaoru Takakusaki; Un Jung Kang; Serge Przedborski; Stella M Papa; MDS-Scientific Issues Committee

doi:10.1002/mds.28883

Discussion of Research Priorities for Gait Disorders in Parkinson's Disease

Mov Disord. 2022 Feb;37(2):253-263. doi: 10.1002/mds.28883. Epub 2021 Dec 22.

Authors

Affiliations

¹ Departments of Radiology and Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.
² Departments of Neuroscience and Neurology, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York, USA.
³ Departments of Neurology and Neuroscience, The Peter O'Donnell Jr. Brain Institute, UT Southwestern, Dallas, Texas, USA.
⁴ Jean and Paul Amos Parkinson's Disease and Movement Disorders Program, Emory University School of Medicine, Atlanta, Georgia, USA.
⁵ Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
⁶ Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
⁷ ForeFront Parkinson's Disease Research Clinic, Brain and Mind Centre, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
⁸ Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
⁹ Movement Disorder Section, Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA.
¹⁰ Department of Physiology, Section of Neuroscience, Asahikawa Medical University, Asahikawa, Japan.
¹¹ Departments of Neurology, Neuroscience, and Physiology, Neuroscience Institute, The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, The Parekh Center for Interdisciplinary Neurology, New York University Grossman School of Medicine, New York, New York, USA.
¹² Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Columbia University, New York, New York, USA.
¹³ Department of Neurology, School of Medicine, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Abstract

Gait and balance abnormalities develop commonly in Parkinson's disease and are among the motor symptoms most disabling and refractory to dopaminergic or other treatments, including deep brain stimulation. Efforts to develop effective therapies are challenged by limited understanding of these complex disorders. There is a major need for novel and appropriately targeted research to expedite progress in this area. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society has charged a panel of experts in the field to consider the current knowledge gaps and determine the research routes with highest potential to generate groundbreaking data. © 2021 International Parkinson and Movement Disorder Society.

Keywords: FOG; Parkinson's disease; balance; freezing; gait; research priorities.

Publication types

Review

MeSH terms

Dopamine
Gait / physiology
Gait Disorders, Neurologic* / etiology
Gait Disorders, Neurologic* / therapy
Humans
Parkinson Disease* / complications
Parkinson Disease* / therapy
Research

Substances

Dopamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding