Objective: To compare the clinical therapeutic effect between herb-separated moxibustion on navel combined with Ningmitai capsule and simple Ningmitai capsule for non-liquefaction semen with dampness and heat diffusing downward.
Methods: A total of 66 patients with non-liquefaction semen of dampness and heat diffusing downward were randomized into an observation group (33 cases, 2 cases dropped off) and a control group (33 cases, 2 cases dropped off). In the control group, Ningmitai capsule was given orally 3 times a day. On the basis of the control group, herb-separated moxibustion on navel was applied in the observation group, 5 moxa-cones each time, once a week. The 4-time treatment was as one course and totally 3 courses were required in the both groups. Before and after treatment, the semen quality indexes (time of semen liquefaction, sperm viability, total sperm motility, number of progressive motility sperms, sperm concentration and semen volume) and TCM syndrome score were observed, the clinical therapeutic efficacy and spouse pregnancy rate were evaluated in the two groups.
Results: After treatment, the time of semen liquefaction was shortened (P<0.05), the sperm viability, total sperm motility, number of progressive motility sperms, sperm concentration and semen volume were increased in the both groups (P<0.05); the time of semen liquefaction in the observation group was shorter than the control group (P<0.05), the sperm viability, total sperm motility and number of progressive motility sperms in the observation group were superior to the control group (P<0.05). After treatment, the TCM syndrome score was decreased compared before treatment in the observation group (P<0.05), and that in the observation group was lower than the control group (P<0.05). The total therapeutic effect rate and spouse pregnancy rate were 93.5% (29/31) and 67.7% (21/31) in the observation group, which were higher than 71.0% (22/31) and 41.9% (13/31) in the control group respectively (P<0.05).
Conclusion: Herb-separated moxibustion on navel combined with Ningmitai capsule can effectively treat non-liquefaction semen with dampness and heat diffusing downward, improve the clinical symptoms, semen quality and spouse pregnancy rate, the therapeutic effect is superior to simple oral Ningmitai capsule.
目的：比较隔药灸脐法联合宁泌泰胶囊与单纯宁泌泰胶囊治疗湿热下注型精液不液化的临床疗效。方法：将66例湿热下注型精液不液化患者随机分为观察组（33例，脱落2例）和对照组（33例，脱落2例）。对照组口服宁泌泰胶囊，每天3次；观察组在对照组基础上加用隔药灸脐治疗，每次灸5壮，每周治疗1次。两组均治疗4次为一疗程，连续治疗3个疗程。分别于治疗前后观察两组精液质量指标（精液液化时间、精子活率、精子总活力、前向运动精子数、精子浓度、精液量）及中医证候积分，并评定两组临床疗效及配偶妊娠率。结果：治疗后，两组患者精液液化时间缩短（P<0.05），精子活率、精子总活力、前向运动精子数、精子浓度和精液量增加（P<0.05）；观察组精液液化时间短于对照组（P<0.05），精子活率、精子总活力及前向运动精子数高于对照组（P<0.05）。观察组治疗后中医证候积分较治疗前降低（P<0.05），且低于对照组（P<0.05）。观察组治疗总有效率、配偶妊娠率分别为93.5%（29/31）和67.7%（21/31），高于对照组的71.0%（22/31）和 41.9%（13/31，P<0.05）。结论：隔药灸脐法联合宁泌泰胶囊可有效治疗湿热下注型精液不液化，改善患者临床症状、精液质量，提高患者配偶妊娠率，疗效优于单纯口服宁泌泰胶囊。.
Keywords: Ningmitai capsule; dampness and heat diffusing downward; herb-separated moxibustion; non-liquefaction semen; semen quality.