Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors

Thao M Xiong; Edzna S Garcia; Junfeng Chen; Lingyang Zhu; Ariale J Alzona; Steven C Zimmerman

doi:10.1039/d1cc05578j

Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors

Chem Commun (Camb). 2022 Jan 20;58(7):985-988. doi: 10.1039/d1cc05578j.

Authors

Thao M Xiong¹, Edzna S Garcia¹, Junfeng Chen¹, Lingyang Zhu², Ariale J Alzona¹, Steven C Zimmerman¹

Affiliations

¹ Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. sczimmer@illinois.edu.
² NMR Laboratory, School of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana 61801, USA.

PMID: 34935784
DOI: 10.1039/d1cc05578j

Abstract

We report a modular approach in which a noncovalently cross-linked single chain nanoparticle (SCNP) selectively binds catalyst "cofactors" and substrates to increase both the catalytic activity of a Cu-catalyzed alkyne-azide cycloaddition reaction and the Ru-catalyzed cleavage of allylcarbamate groups compared to the free catalysts.

MeSH terms

Alkynes / chemistry
Allyl Compounds / chemistry
Allyl Compounds / metabolism
Azides / chemistry
Catalysis
Copper / chemistry
Cycloaddition Reaction
Glutathione / chemistry
Nanoparticles / chemistry*
Ruthenium / chemistry
Transition Elements / chemistry*

Substances

Alkynes
Allyl Compounds
Azides
Transition Elements
Copper
Ruthenium
Glutathione