Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

Timothy M Rawson; Richard C Wilson; Luke S P Moore; Alasdair P Macgowan; Andrew M Lovering; Mark Bayliss; Mathew Kyriakides; Mark Gilchrist; Jason A Roberts; William W Hope; Alison H Holmes

doi:10.1093/ofid/ofab573

Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

Open Forum Infect Dis. 2021 Dec 18;8(12):ofab573. doi: 10.1093/ofid/ofab573. eCollection 2021 Dec.

Authors

Timothy M Rawson^{1

2}, Richard C Wilson^{1

2}, Luke S P Moore^{1

3

4}, Alasdair P Macgowan⁵, Andrew M Lovering⁵, Mark Bayliss⁵, Mathew Kyriakides⁵, Mark Gilchrist^{1

2}, Jason A Roberts⁶, William W Hope⁷, Alison H Holmes^{1

2}

Affiliations

¹ National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK.
² Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, London, UK.
³ Chelsea & Westminster NHS Foundation Trust, London, UK.
⁴ Central London Community Healthcare NHS Trust, London, UK.
⁵ Department of Infection Sciences, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
⁶ Burns Trauma and Critical Care Research Centre and Centre for Translational Pharmacodynamics, The University of Queensland, Brisbane, Australia.
⁷ Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

Abstract

This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.

Keywords: healthy volunteers; oral dosing; penicillin-V; pharmacokinetics; population PK modeling.