Tumor Microenvironment Responsive Single-Atom Nanozymes for Enhanced Antitumor Therapy

Mengyu Chang; Zhiyao Hou; Man Wang; Chunxia Li; Abdulaziz A Al Kheraif; Jun Lin

doi:10.1002/chem.202104081

Tumor Microenvironment Responsive Single-Atom Nanozymes for Enhanced Antitumor Therapy

Chemistry. 2022 Mar 10;28(15):e202104081. doi: 10.1002/chem.202104081. Epub 2022 Jan 12.

Authors

Mengyu Chang¹, Zhiyao Hou^{2

3}, Man Wang⁴, Chunxia Li⁴, Abdulaziz A Al Kheraif⁵, Jun Lin^{1

6}

Affiliations

¹ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
² Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, 511436, P. R. China.
³ Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, P. R. China.
⁴ Institute of Molecular Sciences and Engineering, Shandong University, Qingdao, 266237, P. R. China.
⁵ Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, 12372, Saudi Arabia.
⁶ School of Applied Chemistry and Engineering, University of Sciences and Technology of China, Hefei, 230026, P. R. China.

PMID: 34931345
DOI: 10.1002/chem.202104081

Abstract

Single-atom nanozymes (SAzymes) with specific response to the unique tumor microenvironment (TME) feature providing 100 % metal atoms utilization for high-efficient enzyme-catalyzed therapy and accurate template for the study of therapeutic mechanisms. In this review, we first introduce the various synthetic strategies of SAzymes, and the TME-responsive SAzymes activities. Next, the TME-responsive enhanced antitumor therapeutic approaches based on the enzymatic activities of SAzymes are summarized, and the corresponding therapy mechanisms are elaborated. Subsequently, a concise but concentrated summary, and the challenges and opportunities for the future design and engineering of SAzyme are outlined. As a new discipline, SAzymes have vast space for development in enhanced antitumor therapy. This timely review provides guidance and constructive suggestions for the future of SAzymes.

Keywords: SAzymes; TME-responsive; high enzyme activity; therapy mechanism.

Publication types

Review

MeSH terms

Catalysis
Tumor Microenvironment*

Abstract

Publication types

MeSH terms

Grants and funding