Shared postulations between bipolar disorder and polycystic ovary syndrome pathologies

Wenyu Dai; Jieyu Liu; Yan Qiu; Ziwei Teng; Sujuan Li; Jing Huang; Hui Xiang; Hui Tang; Bolun Wang; Jindong Chen; Haishan Wu

doi:10.1016/j.pnpbp.2021.110498

Shared postulations between bipolar disorder and polycystic ovary syndrome pathologies

Prog Neuropsychopharmacol Biol Psychiatry. 2022 Apr 20:115:110498. doi: 10.1016/j.pnpbp.2021.110498. Epub 2021 Dec 18.

Authors

Wenyu Dai¹, Jieyu Liu², Yan Qiu¹, Ziwei Teng¹, Sujuan Li¹, Jing Huang¹, Hui Xiang¹, Hui Tang¹, Bolun Wang³, Jindong Chen⁴, Haishan Wu⁵

Affiliations

¹ National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
² Department of Ultrasound Diagnostic, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
³ Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
⁴ National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China. Electronic address: chenjindong@csu.edu.cn.
⁵ National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China. Electronic address: wuhaishan@csu.edu.cn.

PMID: 34929323
DOI: 10.1016/j.pnpbp.2021.110498

Abstract

Introduction: Women with bipolar disorder (BD) present a high prevalence of polycystic ovary syndrome (PCOS) and other reproductive disorders even before diagnosis or treatment of the disease. Postulations on the potential molecular mechanisms of comorbid PCOS in women with BD remain limited to influence of medications and need further extension.

Objectives: This review focuses on evidence suggesting that common metabolic and immune disorders may play an important role in the development of BD and PCOS.

Results: The literature covered in this review suggests that metabolic and immune disorders, including the dysfunction of the hypothalamic-pituitary-adrenal axis, chronic inflammatory state, gut microbial alterations, adipokine alterations and circadian rhythm disturbance, are observed in patients with BD and PCOS. Such disorders may be responsible for the increased prevalence of PCOS in the BD population and indicate a susceptibility gene overlap between the two diseases. Current evidence supports postulations of common metabolic and immune disorders as endophenotype in BD as well as in PCOS.

Conclusions: Metabolic and immune disorders may be responsible for the comorbid PCOS in the BD population. The identification of hallmark metabolic and immune features common to these two diseases will contribute to the clarification of the effect of BD on the reproductive endocrine function and development of symptomatic treatments targeting the biomarkers of the two diseases.

Keywords: Bipolar disorder; Comorbidity; Metabolic disorders; Polycystic ovary syndrome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bipolar Disorder* / epidemiology
Bipolar Disorder* / physiopathology
Circadian Rhythm / physiology
Comorbidity*
Female
Humans
Hypothalamo-Hypophyseal System / physiopathology*
Immune System Diseases / complications
Metabolic Diseases / complications
Pituitary-Adrenal System / physiopathology*
Polycystic Ovary Syndrome* / epidemiology
Polycystic Ovary Syndrome* / physiopathology